Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5.

@article{Murillo2005ChemopreventionOC,
  title={Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5.},
  author={Genoveva Murillo and Rajendra G. Mehta},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2005},
  volume={97 1-2},
  pages={129-36}
}
Epidemiological data as well as experimental models yield evidence for a protective effect of vitamin D against the genesis of several types of cancers. Given its toxic properties at effective concentrations, numerous analogs of vitamin D have been developed. We synthesized an analog of vitamin D(5), 1alpha-hydroxy-24-ethylcholechalciferol (1alpha(OH)D(5)) and previously reported on its anti-proliferative activities against several cancer cell lines. To further examine its chemopreventive… CONTINUE READING
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