Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.

Abstract

The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc expression. Inhibition of ornithine decarboxylase, an enzyme of the polyamine biosynthetic pathway… (More)
DOI: 10.1158/1940-6207.CAPR-09-0166

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@article{Forshell2010ChemopreventionOB, title={Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.}, author={TachaZi Plym Forshell and Sara Rimpi and Jonas A. Nilsson}, journal={Cancer prevention research}, year={2010}, volume={3 2}, pages={140-7} }