Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.

@article{Sumiyoshi1990ChemopreventionO1,
  title={Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.},
  author={Hiromichi Sumiyoshi and Michael J. Wargovich},
  journal={Cancer research},
  year={1990},
  volume={50 16},
  pages={5084-7}
}
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipid- and four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and S-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1… CONTINUE READING