Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model.

@article{Shibata1993ChemopreventionBI,
  title={Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model.},
  author={Masa‐aki Shibata and Ryuichi Hasegawa and Tomoyuki Shirai and Yasuko Takesada and Shoji Fukushima},
  journal={International journal of cancer},
  year={1993},
  volume={55 6},
  pages={1011-7}
}
The chemopreventive effects of indomethacin (IM) on the enhancement of bladder carcinogenesis and transitional-epithelial-cell proliferation by butylated hydroxyanisole (BHA) or sodium L-ascorbate (Na-AsA) were investigated. All animals were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in their drinking water for 4 weeks. They then received 2% BHA or 5% Na-AsA for 20 weeks, followed by 20 ppm IM in the drinking water or normal tap water without supplement for a further 20 weeks, or… CONTINUE READING
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