Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study.

@article{Lissoni1999ChemoneuroendocrineTO,
  title={Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study.},
  author={Paolo Lissoni and Gabriele Tancini and F. Paolorossi and Mario Mandal{\`a} and Antonio Ardizzoia and Fabio Malugani and Luisa Giani and Sandro Barni},
  journal={Journal of pineal research},
  year={1999},
  volume={26 3},
  pages={169-73}
}
Thrombocytopenia is a frequent complication of cancer and constitutes an absolute contraindication for chemotherapy. Recent studies have demonstrated that platelet generation may be influenced by both cytokines and neurohormones. In particular, the pineal indole melatonin has been proven to enhance platelet number in patients with thrombocytopenia due to… CONTINUE READING