Chemometrics applications in biotechnology processes: predicting column integrity and impurity clearance during reuse of chromatography resin.

Abstract

Separation media, in particular chromatography media, is typically one of the major contributors to the cost of goods for production of a biotechnology therapeutic. To be cost-effective, it is industry practice that media be reused over several cycles before being discarded. The traditional approach for estimating the number of cycles a particular media can… (More)
DOI: 10.1002/btpr.1610

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Cite this paper

@article{Rathore2012ChemometricsAI, title={Chemometrics applications in biotechnology processes: predicting column integrity and impurity clearance during reuse of chromatography resin.}, author={Anurag S. Rathore and Shachi Mittal and Scott C Lute and Kurt A. Brorson}, journal={Biotechnology progress}, year={2012}, volume={28 5}, pages={1308-14} }