Chemomechanically engineered 3D organotypic platforms of bladder cancer dormancy and reactivation.

Abstract

Tumors undergo periods of dormancy followed by reactivation leading to metastatic disease. Arrest in the G0/G1 phase of the cell cycle and resistance to chemotherapeutic drugs are key hallmarks of dormant tumor cells. Here, we describe a 3D platform of bladder cancer cell dormancy and reactivation facilitated by a novel aminoglycoside-derived hydrogel… (More)
DOI: 10.1016/j.biomaterials.2017.07.008

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