Chemokines released from astroglia by vasoactive intestinal peptide. Mechanism of neuroprotection from HIV envelope protein toxicity.

@article{Brenneman2000ChemokinesRF,
  title={Chemokines released from astroglia by vasoactive intestinal peptide. Mechanism of neuroprotection from HIV envelope protein toxicity.},
  author={Douglas E. Brenneman and Janet Hauser and Catherine Y. Spong and Terry M Phillips},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={921},
  pages={109-14}
}
The mechanism through which VIP prevents neurotoxicity associated with HIV envelope protein has been shown to involve the release of a beta-chemokine, MIP-1 alpha. Astrocytes stimulated with subnanomolar concentrations of VIP caused the release of MIP-1 alpha and RANTES, both of which have been shown to prevent neuronal cell death associated with gp120. It is further proposed that gp120 causes neuronal cell death, in part, by competing with endogenous chemokines at various chemokines receptors… CONTINUE READING
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