Chemokines regulate the migration of neural progenitors to sites of neuroinflammation.

  title={Chemokines regulate the migration of neural progenitors to sites of neuroinflammation.},
  author={Abdelhak A. Belmadani and Phuong B. Tran and Dongjun Ren and Richard J. Miller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={26 12},
Many studies have shown that transplanted or endogenous neural progenitor cells will migrate toward damaged areas of the brain. However, the mechanism underlying this effect is not clear. Here we report that, using hippocampal slice cultures, grafted neural progenitor cells (NPs) migrate toward areas of neuroinflammation and that chemokines are a major regulator of this process. Migration of NPs was observed after injecting an inflammatory stimulus into the area of the fimbria and transplanting… CONTINUE READING
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