Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease.

@article{Fuke2004ChemokinesIB,
  title={Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease.},
  author={Satoshi Fuke and Tomoko Betsuyaku and Yasuyuki Nasuhara and Toshiaki Morikawa and Hiroyuki Katoh and Masaharu Nishimura},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 4},
  pages={
          405-12
        }
}
The inflammatory chemokines interleukin-8, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1, are reportedly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Although bronchiolar epithelial cells and macrophages are known to be the cellular sources, the relative contribution of each cell type remains to be elucidated. In the present study, we first quantified cytokine mRNA in human bronchiolar epithelial cells and macrophages obtained… CONTINUE READING
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