Chemokines direct endothelial progenitors into tumor neovessels.

  title={Chemokines direct endothelial progenitors into tumor neovessels.},
  author={Herbert Spring and Thomas Sch{\"u}ler and Bernd Arnold and G{\"u}nter J. H{\"a}mmerling and Ruth Ganss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 50},
Tumor neovasculature substantially derives from sprouting of existing vessels, whereas the functional contribution of bone marrow-derived progenitors to neovessels remains controversial. We used transgenic mouse models of multistep carcinogenesis to monitor incorporation of bone marrow-derived cells into the neovasculature and to elucidate mechanisms of endothelial precursor cell (EPC) recruitment into the tumor microenvironment. We unequivocally demonstrate integration of bone marrow cells… CONTINUE READING