Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia

@inproceedings{Mukaida2017ChemokinesAA,
  title={Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia},
  author={Naofumi Mukaida and Yamato Tanabe and Tomohisa Baba},
  booktitle={International journal of molecular sciences},
  year={2017}
}
All blood lineage cells are generated from hematopoietic stem cells (HSCs), which reside in bone marrow after birth. HSCs self-renew, proliferate, and differentiate into mature progeny under the control of local microenvironments including hematopoietic niche, which can deliver regulatory signals in the form of bound or secreted molecules and from physical cues such as oxygen tension and shear stress. Among these mediators, accumulating evidence indicates the potential involvement of several… CONTINUE READING

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