Chemokines and the tissue-specific migration of lymphocytes.

@article{Kunkel2002ChemokinesAT,
  title={Chemokines and the tissue-specific migration of lymphocytes.},
  author={E. Kunkel and E. Butcher},
  journal={Immunity},
  year={2002},
  volume={16 1},
  pages={
          1-4
        }
}
Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous and intestinal memory T cells, and of IgA plasma… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
TLDR
The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues. Expand
The β7 integrins in mucosal homing and retention
TLDR
Members of the β7 subfamily of integrins, αEβ7 and α4β7, and their counter-receptors, are believed to play key roles in directing lymphocyte traffic to and retention in mucosal organs. Expand
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
TLDR
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Expand
The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System1
TLDR
It is suggested that the selective expression of TECK in the small bowel underlie the homing of CCR9+ intestinal memory T cells to theSmall bowel rather than to the colon, which implies a segregation of small intestinal from colonic immune responses. Expand
CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells.
  • J. Morales, B. Homey, +8 authors A. Zlotnik
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
An important role is suggested for CTACK in recruitment of CLA(+) T cells to cutaneous sites and it is suggested that CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes. Expand
Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues
TLDR
During an immune response, local microenvironments within cutaneous and intestinal secondary lymphoid organs differentially direct T cell expression of these adhesion and chemoattractant receptors, targeting the resulting effector T cells to the inflamed skin or intestinal lamina propria. Expand
The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells
TLDR
Thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node, thus helping define and segregate the intestinal immune response. Expand
Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects1
TLDR
This study provides added support for the concept of a lung-homing pathway separate from other mucosal organs such as the gut and suggests that the chemokine pathways that control T cell migration in normal homeostasis and Th2-type inflammatory responses are similar. Expand
Lymphocyte trafficking and regional immunity.
TLDR
The chapter discusses the present understanding of tissue-selective lymphocyte trafficking, focusing in particular on the gut and its associated lymphoid tissues, with emphasis on the importance of these mechanisms for the understanding and manipulation of regional immune responses in the gastrointestinal tract. Expand
Selective chemotaxis of subsets of B lymphocytes from gut-associated lymphoid tissue and its implications for the recruitment of mucosal plasma cells.
TLDR
The data are consistent with the idea that precursors of mucosal IgA plasma cells home to mucosal and exocrine sites in response to a specific chemotactic factor elaborated by local differentiated epithelial cells. Expand
...
1
2
3
...