Alcohol–Chemokine Interaction and Neurotransmission
Chemokines that act to recruit cells of the immune system to a site of injury or infection are considered to be proinflammatory chemokines, whereas chemokine that are involved in chemotaxis during normal processes of tissue maintenance or development are considered of homeostatic in function.
Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks
- Biology, MedicineJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
The value of evidence obtained from the use of Ccl2- and Cxcr2-deficient mice will be reported, in the context of potential therapeutics inhibiting chemokine activity which are currently in clinical trial for various inflammatory diseases.
Cytokines, Masticatory Muscle Inflammation, and Pain: an Update
- BiologyJournal of Molecular Neuroscience
Several types of pro- and anti-inflammatory mediators and their relation with inflammatory pain in masticatory muscles are discussed.
Stimulatory role of the chemokine CCL2 in the migration and peptide expression of embryonic hypothalamic neurons
- BiologyJournal of neurochemistry
Evidence is provided for a stimulatory effect of CCL2 on embryonic hypothalamic neurons involving changes in migratory behavior, expression, and synthesis of neuropeptides that function in controlling behavior.
A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders
- BiologyCurrent neuropharmacology
The role of chemokine in the central nervous system under physiological and pathological conditions and their involvement in processes underlying depressive disorder are outlined.
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area
- BiologyScientific reports
It is demonstrated for the first time that CXCL16 exerts a modulatory activity on inhibitory and excitatory synaptic transmission in CA1 area and it is found that CxCL16 increases the frequency of the miniature inhibitory synaptic currents and the paired-pulse ratio of evoked IPSCs, suggesting a presynaptic modulation of the probability of GABA release.
The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy
- Biology, MedicineJournal of diabetes research
Findings indicate that the chemokines CXCL1, C XCL5, CxCL9, and CXCl12 are important in nociceptive transmission and may play a role in the development of diabetic neuropathy.
A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators
- Biology, ChemistryMetabolic Brain Disease
PIC challenge elicits a broad upregulation of cerebral chemokine genes, and this upregulation is mediated by blood-borne agents, and could be induced in naïve mice by transfer of blood plasma from PIC-challenged mice.
SHOWING 1-10 OF 67 REFERENCES
Chemokines: a new class of neuromodulator?
- Biology, PsychologyNature Reviews Neuroscience
These findings, together with the pharmacological development of agonists and antagonists that are selective for chemokine receptors and can cross the blood–brain barrier, open a new era of research in neuroscience.
Differential production of and migratory response to beta chemokines by human microglia and astrocytes.
- BiologyThe Journal of infectious diseases
The results of this in vitro study suggest that beta chemokines may play an important role in the trafficking of mononuclear phagocytes within the brain.
The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4.
- BiologyProceedings of the National Academy of Sciences of the United States of America
It is demonstrated that chemokine actions in the brain are not restricted to inflammatory processes and proposed to add to the known autoregulation of AVP on its own neurons, a second autocrine system induced by SDF-1 able to modulate central AVP neuronal activity and release.
Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity.
- BiologyJournal of molecular endocrinology
This review focuses on current knowledge about the actions of this chemokine on neuronal excitability, through CXCR4 or other yet unknown pathways, and the possible mechanisms underlying these effects and their consequences in terms of modulation of neuroendocrine systems and physiopathology are discussed.
Chemokines and disease
- Biology, MedicineNature Immunology
Several diseases that are associated with inappropriate activation of the chemokine network are examined, including cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease.
Constitutive expression of CCR2 chemokine receptor and inhibition by MCP‐1/CCL2 of GABA‐induced currents in spinal cord neurones
- BiologyJournal of neurochemistry
The aim of the present work was to investigate further, both in vivo and in vitro, CC Chemokine Family Receptor 2 (CCR2) expression and functionality in rat spinal cord neurones, and to contribute to the understanding of the roles of CCR2 and MCP‐1/CCL2 in spinal cord physiology, in particular with respect to nociceptive transmission.
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
It is proposed that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment.
Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells
- Biology, MedicineJournal of Neuroimmunology
Electrophysiological analysis of neuronal chemokine receptors.
Monocyte chemoattractant protein (MCP)-1 is rapidly expressed by sympathetic ganglion neurons following axonal injury
- Biology, MedicineNeuroreport
ED1-immunoreactive macrophages, absent from the superior cervical ganglia of normal rats, appear in these ganglia within 48 h after postganglionic axotomy, and axotomy-induced neuronal MCP-1 expression may trigger the infiltration and/or activation of macrophage in SCG after injury.