Chemokines and disease

  title={Chemokines and disease},
  author={Craig J. Gerard and Barrett J Rollins},
  journal={Nature Immunology},
We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to… 
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The chemokine system in neuroinflammation: an update.
  • R. Ransohoff
  • Medicine, Biology
    The Journal of infectious diseases
  • 2002
This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes and animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis are considered.
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This chapter will briefly review the properties of chemokines and their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.
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Targeting chemokines and/or chemokine receptors appears to be an intriguing new approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory bowel diseases, multiple
Chemokines and Their Receptors
This work reviews information available on the role of chemokines in selected human diseases and provides examples of clinical situations in which chemokine determination might be of practical value, and describes the currently available assays for their measurement.
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Recent developments concerning the role of chemokines in diseases of the central nervous system (CNS) as well as their possible therapeutic relevance are discussed.
Chemokines and their receptors in central nervous system disease
Recent developments concerning the role of chemokines in diseases of the central nervous system (CNS) as well as their possible therapeutic relevance are discussed.


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Chemokines and their receptors in allograft rejection.
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A role for MCP-1 in the development of early atherosclerotic lesions is revealed and upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation.
Current understanding of chemokine involvement in allograft transplantation
It is possible that chemokine‐targeted therapy might become a feasible option for the treatment of allograft rejection and these molecules may serve as sensitive diagnostic indicators for the analysis of rejection, including chronic rejection or other forms of graft dysfunction.
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This research has shown that CXC R2 is strongly expressed on macrophages in atherosclerotic lesion and this CXCR2 expression is proatherogenic in that C XCR2 deficiency significantly reduces the progression of advanced atherosclerosis in mice.
Dancing to the tune of chemokines
Recent advances in the elucidation of the signal transduction that occurs in proximity to receptors and that leads to the early biochemical events in leukocyte activation are discussed.
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Eotaxin and its receptor, CCR3, are overexpressed in human atherosclerosis, suggesting that eotaxIn participates in vascular inflammation, demonstrating how genomic differential expression technology can identify novel genes that may participate in the stability of atherosclerotic lesions.
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)
Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory lesions in experimental autoimmune encephalomyelitis (EAE), a murine model
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