Chemokines and disease

@article{Gerard2001ChemokinesAD,
  title={Chemokines and disease},
  author={Craig J. Gerard and Barrett J Rollins},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={108-115}
}
We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to… 
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1,406 Citations
Highly Influential Citations
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532
Methods Citations
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1,406 Citations

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The role of chemokines in inflammatory joint diseases, with particular emphasis on rheumatoid arthritis, is explored in this review.
The chemokine system in neuroinflammation: an update.
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This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes and animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis are considered.
Chemokines and diseases.
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This review focuses on the physiology of chemokines and their significant roles in the pathogenesis and progression of major diseases.
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This chapter will briefly review the properties of chemokines and their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.
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The role of chemokines in health and diseases is examined, strategies to target the chemokine system are discussed, and several promising drugs are currently being tested in late-stage clinical trials.
Chemokines in joint disease: the key to inflammation?
Targeting chemokines and/or chemokine receptors appears to be an intriguing new approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory bowel diseases, multiple…
Chemokines as novel therapeutic targets in inflammatory diseases.
Chemokines and Their Receptors
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This work reviews information available on the role of chemokines in selected human diseases and provides examples of clinical situations in which chemokine determination might be of practical value, and describes the currently available assays for their measurement.
Chemokines and their receptors in central nervous system disease.
TLDR
Recent developments concerning the role of chemokines in diseases of the central nervous system (CNS) as well as their possible therapeutic relevance are discussed.
Chemokines and their receptors in central nervous system disease
TLDR
Recent developments concerning the role of chemokines in diseases of the central nervous system (CNS) as well as their possible therapeutic relevance are discussed.
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References

SHOWING 1-10 OF 140 REFERENCES
Chemokines and chemokine receptors in model neurological pathologies: molecular and immunocytochemical approaches.
Chemokines and their receptors in allograft rejection.
Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis
TLDR
A role for MCP-1 in the development of early atherosclerotic lesions is revealed and upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation.
Current understanding of chemokine involvement in allograft transplantation
TLDR
It is possible that chemokine‐targeted therapy might become a feasible option for the treatment of allograft rejection and these molecules may serve as sensitive diagnostic indicators for the analysis of rejection, including chronic rejection or other forms of graft dysfunction.
Interleukin-8 and its receptor CXCR2 in atherosclerosis
TLDR
This research has shown that CXC R2 is strongly expressed on macrophages in atherosclerotic lesion and this CXCR2 expression is proatherogenic in that C XCR2 deficiency significantly reduces the progression of advanced atherosclerosis in mice.
Dancing to the tune of chemokines
TLDR
Recent advances in the elucidation of the signal transduction that occurs in proximity to receptors and that leads to the early biochemical events in leukocyte activation are discussed.
Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis: Using Genomic Technology to Identify a Potential Novel Pathway of Vascular Inflammation
TLDR
Eotaxin and its receptor, CCR3, are overexpressed in human atherosclerosis, suggesting that eotaxIn participates in vascular inflammation, demonstrating how genomic differential expression technology can identify novel genes that may participate in the stability of atherosclerotic lesions.
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)
Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory lesions in experimental autoimmune encephalomyelitis (EAE), a murine model…
The CCR5 deletion mutation fails to protect against multiple sclerosis.
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
TLDR
The results imply pathogenic roles for specific chemokine-chemokine receptor interactions in MS and suggest new molecular targets for therapeutic intervention.
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