Chemokines and chemokine receptors: positioning cells for host defense and immunity.

  title={Chemokines and chemokine receptors: positioning cells for host defense and immunity.},
  author={Jason W. Griffith and Caroline L. Sokol and Andrew D. Luster},
  journal={Annual review of immunology},
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein-coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important… 

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