Chemokines and chemokine receptors: positioning cells for host defense and immunity.

@article{Griffith2014ChemokinesAC,
  title={Chemokines and chemokine receptors: positioning cells for host defense and immunity.},
  author={Jason W. Griffith and Caroline L. Sokol and Andrew D. Luster},
  journal={Annual review of immunology},
  year={2014},
  volume={32},
  pages={
          659-702
        }
}
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein-coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important… 
View on PubMed
massgeneral.org
1,363 Citations
Highly Influential Citations
72
Background Citations
576
Methods Citations
15
Results Citations
12

Figures and Tables from this paper

1,363 Citations

Chemokine-guided cell positioning in the lymph node orchestrates the generation of adaptive immune responses.

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics.

This review focuses on the role of the chemokine system in the migration dynamics of immune cells within lymphoid organs at the steady state and on how these dynamics are affected by infectious and inflammatory processes.

Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics

This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the whole organ level in homeostasis, inflammation, and infection.

Chemokine and chemotactic signals in dendritic cell migration

Understanding the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and the actions of atypical chemokine receptors will uncover new molecular targets for therapeutic interventions.

Chemokines and the immune response to cancer.

Chemokines in homeostasis and diseases

The functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis, inflammation, immune responses and cancer are introduced.

Chemokine regulation of innate lymphoid cell tissue distribution and function.

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

It appears as the CCR7–CCL19/CCL21 axis is tightly regulated at numerous intersections, and the understanding of the molecular determinants of biased signaling and the multiple layers of C CR7 regulation holds the promise for potential future therapeutic intervention.

Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells.

Chemokines in cellular positioning and human disease

  • J. Groom
  • Biology
    Immunology and cell biology
  • 2015
Chemokines constitute the largest family of cytokines, consisting of ~50 endogenous chemokine ligands in humans and mice and have a critical role in all immune cell movement, such as the migration required for immune cell development and organ homeostasis.
...

References

SHOWING 1-10 OF 269 REFERENCES

Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.

This review presents the current understanding of the mechanisms that regulate the cellular perception and pathophysiologic meaning of chemokines and suggests that the specific patterns of homeostatic chemokine patterns are charting lymphocyte navigation routes for immune surveillance.

Orchestrating the orchestrators: chemokines in control of T cell traffic

Advances in understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably are reviewed with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.

Chemokines and NK cells: Regulators of development, trafficking and functions

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.

  • J. Cyster
  • Biology, Medicine
    Annual review of immunology
  • 2005
The steps associated with the initiation of adaptive immune responses in secondary lymphoid organs are reviewed, highlighting the roles of chemokines and S1P.

IL-8 responsiveness defines a subset of CD8 T cells poised to kill.

CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The…

Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation

It is found that in mice infected with lymphocytic choriomeningitis virus, colocalization of virus-specific CD8 T cells with antigen in spleen is dependent on expression of the inflammatory chemokine receptor, CXCR3, andCD8 T-cell positioning relative to antigen and inflammatory cytokines in secondary lymphoid organs affects the balance of effector and memory T- cell formation.

Distinct Chemokine Receptor Axes Regulate Th9 Cell Trafficking to Allergic and Autoimmune Inflammatory Sites

Examining chemokine receptor usage by Th9 cells demonstrates, in models of allergy and autoimmunity, that these cells express functional CCR3, CCR6, and CX CR3,chemokine receptors commonly associated with other, functionally opposed effector Th subsets.

Murine CXCL14 Is Dispensable for Dendritic Cell Function and Localization within Peripheral Tissues

The data indicate that murine CXCL14 is dispensable for the homeostatic recruitment of antigen-presenting cells toward the periphery and for LC functionality.

CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation.

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

It is demonstrated that chemokine receptors are markers of naive and polarized T cell subsets and suggested that flexible programs of chemokin receptor gene expression may control tissue-specific migration of effector T cells.
...