Chemokines and atherosclerotic plaque progression: towards therapeutic targeting?

  title={Chemokines and atherosclerotic plaque progression: towards therapeutic targeting?},
  author={Adriaan O. Kraaijeveld and Saskia C. A. de Jager and Theo J. C. van Berkel and Erik A. L. Biessen and Jan Wouter Jukema},
  journal={Current pharmaceutical design},
  volume={13 10},
Atherosclerosis is currently viewed as an inflammatory disease in which the initiation and progression of the atherosclerotic plaque towards a rupture prone, unstable plaque is driven by leukocyte recruitment mediated by various inflammatory mediators. Recently, interest in chemotactic cytokines or chemokines with regard to atherosclerosis has been growing as chemokines mediate the influx of leukocytes that is typical of atherothrombosis. The activity of the majority of chemokines is… CONTINUE READING


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