Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.

@article{Zhang2014ChemokineTR,
  title={Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.},
  author={Shirley L. Zhang and Xinxin Wang and Sugata Manna and Daniel A. Zlotoff and Jerrod L. Bryson and Bruce R Blazar and Avinash Bhandoola},
  journal={Blood},
  year={2014},
  volume={124 2},
  pages={296-304}
}
Development of T cells in the thymus requires continuous importation of T-lineage progenitors from the bone marrow via the circulation. Following bone marrow transplant, recovery of a normal peripheral T-cell pool depends on production of naïve T cells in the thymus; however, delivery of progenitors to the thymus limits T-lineage reconstitution. Here, we… CONTINUE READING