Chemokine signaling in development and disease.

@article{Wang2014ChemokineSI,
  title={Chemokine signaling in development and disease.},
  author={John Wang and Holger Knaut},
  journal={Development},
  year={2014},
  volume={141 22},
  pages={4199-205}
}
Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. CXCL12 is one of the most evolutionary conserved chemokines and signals through the chemokine receptor CXCR4 to guide cell migration during embryogenesis, immune cell trafficking and cancer metastasis. Here and in the accompanying poster, we provide an overview of chemokine signaling, focusing on… CONTINUE READING
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Emerging targets in cancer management: role of the CXCL12/CXCR4 axis

OncoTargets and therapy • 2013
View 5 Excerpts
Highly Influenced

Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 6 Excerpts
Highly Influenced

Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 5 Excerpts
Highly Influenced

Contribution of endothelial progenitor cells to neovascularization (Review).

International journal of molecular medicine • 2012
View 4 Excerpts
Highly Influenced

Secreted CXCL12 (SDF-1) forms dimers under physiological conditions.

The Biochemical journal • 2012
View 8 Excerpts
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Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 4 Excerpts
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