Chemokine signaling controls endodermal migration during zebrafish gastrulation.

@article{Nair2008ChemokineSC,
  title={Chemokine signaling controls endodermal migration during zebrafish gastrulation.},
  author={Sreelaja Nair and Thomas F Schilling},
  journal={Science},
  year={2008},
  volume={322 5898},
  pages={89-92}
}
Directed cell movements during gastrulation establish the germ layers of the vertebrate embryo and coordinate their contributions to different tissues and organs. Anterior migration of the mesoderm and endoderm has largely been interpreted to result from epiboly and convergent-extension movements that drive body elongation. We show that the chemokine Cxcl12b and its receptor Cxcr4a restrict anterior migration of the endoderm during zebrafish gastrulation, thereby coordinating its movements with… CONTINUE READING
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