Chemokine regulation of atherosclerosis.

  title={Chemokine regulation of atherosclerosis.},
  author={Jana Barlic and Philip G. M. Murphy},
  journal={Journal of leukocyte biology},
  volume={82 2},
Oxidative stress and inflammation are accepted as major factors in the pathogenesis of atherosclerosis, but how they interact to produce a plaque has not been delineated clearly. Recent data suggest that oxidized lipids may act in part by regulating production of chemokines and chemokine receptors, which in turn, may direct monocytes and other blood leukocytes to the vessel wall, where they may interact with endothelial cells and smooth muscle cells. The receptors may act at the level of… CONTINUE READING
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