Chemokine receptors and human immunodeficiency virus infection.

  title={Chemokine receptors and human immunodeficiency virus infection.},
  author={Paul D Bieniasz and Bryan R Cullen},
  journal={Frontiers in bioscience : a journal and virtual library},
Primate lentiviruses infect target cells by interacting with the cell surface protein, CD4 and additional molecules, termed coreceptors. Recently, HIV-1 coreceptors have been identified as seven transmembrane spanning, G-protein coupled receptors of the chemokine receptor family. Thus, expression of CD4 and an appropriate coreceptor is both necessary and sufficient to render target cell permissive for fusion with virions or infected cells. The spectrum of tissue tropisms exhibited by primate… CONTINUE READING
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