Chemokine receptors and cortical interneuron dysfunction in schizophrenia.

  title={Chemokine receptors and cortical interneuron dysfunction in schizophrenia.},
  author={David W. Volk and Anjani Chitrapu and Jessica R Edelson and David A. Lewis},
  journal={Schizophrenia research},
  volume={167 1-3},
Alterations in inhibitory (GABA) neurons, including deficiencies in the GABA synthesizing enzyme GAD67, in the prefrontal cortex in schizophrenia are pronounced in the subpopulations of neurons that contain the calcium-binding protein parvalbumin or the neuropeptide somatostatin. The presence of similar illness-related deficits in the transcription factor Lhx6, which regulates prenatal development of parvalbumin and somatostatin neurons, suggests that cortical GABA neuron dysfunction may be… CONTINUE READING
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