Chemokine receptors and HIV.

  title={Chemokine receptors and HIV.},
  author={Christopher C. Broder and Ronald G. Collman},
  journal={Journal of leukocyte biology},
  volume={62 1},
The discovery that chemokine receptors are the human cofactors required along with CD4 for fusion and infection by HIV has opened new directions in AIDS research on mechanisms of viral entry, tropism, and pathogenesis. A possible mechanism of co-receptor function has been demonstrated that involves the formation of a complex on the cell surface between the HIV-1 envelope, CD4, and the coreceptor. Functional studies indicate that this interaction is structurally complex, that it probably… CONTINUE READING