Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis

@article{Yi2004ChemokineRU,
  title={Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis},
  author={Yanjie Yi and Chuhee Lee and Qing-Hua Liu and Bruce D Freedman and Ronald G. Collman},
  journal={Journal of NeuroVirology},
  year={2004},
  volume={10},
  pages={91-96}
}
Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 for entry. Macrophages and microglia (M/M) are the principal productively infected brain cells in HIV encephalopathy (HIVE), and neuronal injury is believed to result both from direct effects of viral proteins and indirect effects mediated by macrophage activation and secretion of neurotoxic products. In vitro, direct injury by the viral envelope glycoprotein gp120 can be mediated by neuronal CXCR4, but most… CONTINUE READING
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HIV - 1 gp 120 and chemokine activation of Pyk 2 and mitogen - activated protein kinases in primarymacrophagesmediated by calcium - dependent , pertussis toxininsensitive chemokine receptor signaling

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including metabolic amines such as quinolinic acid; cytokines such as TNF-α; nitric oxide; chemokines; and small molecules such as arachadonic acid metabolites and platelet-activating factor

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