Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages.

  title={Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages.},
  author={Paola Di Marzio and J. Tse and Nathaniel R. Landau},
  journal={AIDS research and human retroviruses},
  volume={14 2},
Monocyte-macrophages can be productively infected by CCR5-specific, but not CXCR4-specific, HIV-1. This could be due either to the absence of this chemokine receptor in this cell lineage or to other, yet undefined cellular cofactors that modulate the coreceptor activity of the CXCR4 in these cells. To investigate the basis of macrophage tropism, we studied the expression of CCR5 and CXCR4, as well as several of the other CC chemokine receptors, on monocyte-macrophages at different stages of… CONTINUE READING