Chemokine receptor oligomerization and allostery.

  title={Chemokine receptor oligomerization and allostery.},
  author={Bryan S. Stephens and Tracy M. Handel},
  journal={Progress in molecular biology and translational science},
Oligomerization of chemokine receptors has been reported to influence many aspects of receptor function through allosteric communication between receptor protomers. Allosteric interactions within chemokine receptor hetero-oligomers have been shown to cause negative cooperativity in the binding of chemokines and to inhibit receptor activation in the case of some receptor pairs. Other receptor pairs can cause enhanced signaling and even activate entirely new, hetero-oligomer-specific signaling… CONTINUE READING

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