Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.

@article{McDermott2003ChemokineRM,
  title={Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.},
  author={David Hugh McDermott and Alan M. Fong and Qiong Yang and Joan M. G. Sechler and L. Adrienne Cupples and Maya N Merrell and Peter W. F. Wilson and Ralph B. D'Agostino and Christopher J. O'Donnell and Dhavalkumar D. Patel and Philip G. M. Murphy},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 8},
  pages={1241-50}
}
The chemokine receptor CX3CR1 is a proinflammatory leukocyte receptor specific for the chemokine fractalkine (FKN or CX3CL1). In two retrospective studies, CX3CR1 has been implicated in the pathogenesis of atherosclerotic cardiovascular disease (CVD) based on statistical association of a common receptor variant named CX3CR1-M280 with lower prevalence of atherosclerosis, coronary endothelial dysfunction, and acute coronary syndromes. However, the general significance of CX3CR1-M280 and its… CONTINUE READING

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