Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival

@inproceedings{Xiang2008ChemokineRC,
  title={Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival},
  author={Zuo-lin Xiang and Zhao-Chong Zeng and Zhao-you Tang and Jia Fan and Peng-yuan Zhuang and Ying Liang and Yun-shan Tan and Jian He},
  booktitle={BMC Cancer},
  year={2008}
}
The chemokine and bone marrow-homing receptor CXCR4 is implicated in metastases of various cancers. This study was conducted to analyze the association of CXCR4 expression with hepatocellular carcinoma (HCC) bone metastasis and patient survival. Tumor tissue from HCC patients with (n = 43) and without (n = 138) bone metastasis was subjected to immunohistochemical staining for CXCR4 using tissue microarrays. Immunoreactivity was evaluated semi-quantitatively. A receiver-operating characteristic… CONTINUE READING