Chemokine receptor 7 knockout attenuates atherosclerotic plaque development.

  title={Chemokine receptor 7 knockout attenuates atherosclerotic plaque development.},
  author={Maren Luchtefeld and Christina Grothusen and Andreas Gagalick and Kumaravelu Jagavelu and Harald Schuett and Uwe J. F. Tietge and Oliver Pabst and K. H. Grote and Helmut Drexler and Reinhold F{\"o}rster and Bernhard Schieffer},
  volume={122 16},
BACKGROUND Atherosclerosis is a systemic inflammatory disease characterized by the formation of atherosclerotic plaques. Both innate immunity and adaptive immunity contribute to atherogenesis, but the mode of interaction is poorly understood. Chemokine receptor 7 (CCR7) is critically involved in the transition from innate to adaptive immune activation by coordinating the migration to and positioning of antigen-presenting dendritic cells and T cells in secondary lymphoid organs. More recently… CONTINUE READING


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