Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome.

@article{Luesink2009ChemokineIB,
  title={Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome.},
  author={Maaike Luesink and Jeroen L. A. Pennings and Willemijn M Wissink and Peter C. M. Linssen and Petra Muus and Rolph Pfundt and Theo de Witte and Bert A van der Reijden and Joop H. Jansen},
  journal={Blood},
  year={2009},
  volume={114 27},
  pages={
          5512-21
        }
}
In acute promyelocytic leukemia (APL), differentiation therapy with all-trans retinoic acid (ATRA) and/or arsenic trioxide can induce a differentiation syndrome (DS) with massive pulmonary infiltration of differentiating leukemic cells. Because chemokines are implicated in migration and extravasation of leukemic cells, chemokines might play a role in DS. ATRA stimulation of the APL cell line NB4 induced expression of multiple CC-chemokines (CCLs) and their receptors (> 19-fold), resulting in… CONTINUE READING
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