Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry.

@article{Yu2005ChemokineglycosaminoglycanBS,
  title={Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry.},
  author={Yonghao Yu and Matthew D Sweeney and Ola M Saad and Susan E Crown and Andro R Hsu and Tracy M. Handel and Julie A. Leary},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 37},
  pages={32200-8}
}
Glycosaminoglycans (GAGs) have recently been demonstrated to be required for the in vivo activity of several chemokines. Minimally, the interaction is thought to provide a mechanism for retention at the site of secretion and the formation of chemokine gradients that provide directional cues for receptor bearing cells, particularly in the presence of shear forces. Thus, a key issue will be to determine the sequence and structure of the GAGs that bind to specific chemokines. Herein, we describe a… CONTINUE READING
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