Chemokine genetic polymorphism in human health and disease.

  title={Chemokine genetic polymorphism in human health and disease.},
  author={Tabish Qidwai},
  journal={Immunology letters},
Chemokine receptor-ligand interaction regulates transmigration of lymphocytes and monocytes from circulation to the inflammatory sites. CC chemokine receptors, chemokine receptor 2(CCR2) and 5 (CCR5) are important in recruitment of immune cells as well as non-immune cells under pathological condition. CCR2, CCR5 and their ligands (CCL2 and CCL5) are major contributor to the autoimmune and inflammatory diseases and cancer. Currently studies are being done to explore genetic variations in… CONTINUE READING