Chemokine expression by subchondral bone marrow stromal cells isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) patients.

@article{Lisignoli1999ChemokineEB,
  title={Chemokine expression by subchondral bone marrow stromal cells isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) patients.},
  author={Gina Lisignoli and Stefania Toneguzzi and Chiara Pozzi and Anna Piacentini and Francesco Grassi and A. M. Ferruzzi and Gualtiero Gualtieri and Andrea Facchini},
  journal={Clinical and experimental immunology},
  year={1999},
  volume={116 2},
  pages={371-8}
}
We analysed the spontaneous and cytokine-stimulated production and expression in vitro of IL-8, GROalpha, MCP-1, RANTES, MIP-1alpha, MIP-1beta, by subchondral bone marrow stromal cells (BMSC) isolated from RA, OA, post-traumatic (PT) patients and normal donors (ND). BMSC were cultured in vitro in the presence or absence of IL-1beta and tumour necrosis factor-alpha (TNF-alpha), and assessed for chemokine production, expression and immunolocalization. BMSC from different sources constitutively… CONTINUE READING

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