Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

@inproceedings{Kurupati2010ChemokinecleavingSP,
  title={Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract},
  author={Prathiba Kurupati and Claire E Turner and Ioanna Tziona and Richard A. Lawrenson and F M Ashraful Alam and Mahrokh Nohadani and Gordon W. H. Stamp and Annelies Sophie Zinkernagel and Victor Nizet and Robert John Edwards and Shiranee Sriskandan},
  booktitle={Molecular microbiology},
  year={2010}
}
SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP expression. SpyCEP cleaved human CXCL1, 2, 6 and 8 plus murine CXCL1 and 2 at a structurally conserved site. Mice were infected in thigh muscle with a strain of S. pyogenes that expresses a high level… CONTINUE READING
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