Chemokine binding protein vCCI attenuates vaccinia virus without affecting the cellular response elicited by immunization with a recombinant vaccinia vector carrying the HPV16 E7 gene.

Abstract

Viral CC chemokine inhibitor (vCCI) of the clone P13 vaccinia virus (VACV) strain PRAHA lacks eight amino acids in the signal peptide sequence. To study the influence of vCCI on virus biology, a virus with the vCCI gene coding for a prolonged signal sequence was prepared. We found that secreted vCCI attenuated the virus in vivo, and that it correlated with… (More)
DOI: 10.1089/vim.2011.0090

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@article{Gabriel2012ChemokineBP, title={Chemokine binding protein vCCI attenuates vaccinia virus without affecting the cellular response elicited by immunization with a recombinant vaccinia vector carrying the HPV16 E7 gene.}, author={Pavel Gabriel and Katarina Babiarov{\'a} and Kamila Zurkova and Jitka Krystofova and Petr Hainz and Luda Kutinov{\'a} and {\vS}{\'a}rka Něme{\vc}kov{\'a}}, journal={Viral immunology}, year={2012}, volume={25 5}, pages={411-22} }