Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

  title={Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches},
  author={Takaharu Okada and Vu N. Ngo and Eric H. Ekland and Reinhold F{\"o}rster and Martin Lipp and Dan R. Littman and Jason G Cyster},
  journal={The Journal of Experimental Medicine},
  pages={65 - 75}
B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4-/- B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4… CONTINUE READING
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