Chemokine Receptors and HIV-1: An Attractive Pair?

  title={Chemokine Receptors and HIV-1: An Attractive Pair?},
  author={Paul Bates},
In addition, CD4 can induce conformational changes in the viral glycoproteins, as measured by antibody epi-Department of Microbiology School of Medicine tope changes and gp120 shedding from the virus (reviewed by Sattentau and Moore, 1993), but viral binding and these conformational changes are not sufficient for HIV-1 infection of cells. In nonhuman cells expressing Binding of virus particles to the host cell surface initiates CD4, HIV-1 binds, but virus–host membrane fusion does not occur… CONTINUE READING


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