Chemokine Receptors: Keys to AIDS Pathogenesis?

  title={Chemokine Receptors: Keys to AIDS Pathogenesis?},
  author={Dan R. Littman},
This major advance followed closely on the heels of the discovery that an activity in lymphocyte supernatants that inhibited HIV replication consisted of three chemo-of macrophage-tropic, but not T cell line–tropic, strains of HIV-1 (Cocchi et al., 1995). Together, these findings set the stage for the demonstration that CCR5, the receptor for the three ␤-chemokines, is the major cofactor Only two years ago, the rapidly expanding families of required for entry of macrophage-tropic strains of HIV… CONTINUE READING
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