Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer.

@article{Perumalsamy2017ChemokineLR,
  title={Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer.},
  author={Sangeetha Perumalsamy and Nurul Ain Aqilah Mohd Zin and Riyanto Teguh Widodo and Wan Azman Wan Ahmad and Shireene Ratna Vethakkan and Hasniza Zaman Huri},
  journal={Current pharmaceutical design},
  year={2017},
  volume={23 25},
  pages={
          3689-3698
        }
}
BACKGROUND Chemerin is an adipokine that induces insulin resistance by the mechanism of inflammation in adipose tissue but these are still unclear. A high level of chemerin in humans is considered as a marker of inflammation in insulin resistance and obesity as well as in type 2 diabetes mellitus. Despite the role of chemerin in insulin resistance progression, chemerin as one of the novel adipokines is proposed to be involved in high cancer risk and mortality. AIM The aim of this paper was to… 
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Role of chemerin in the control of glucose homeostasis
Chemerin: a multifaceted adipokine involved in metabolic disorders
TLDR
A crucial multifaceted role for chemerin in the regulation of energy balance is clearly indicated, making it a promising candidate for urgently needed pharmacological treatment strategies for obesity.
Association of serum chemerin and inflammatory factors with type 2 diabetes macroangiopathy and waist-to-stature ratio.
TLDR
Serum chemerin, factors associated with obesity, pathological and physiological changes in glucolipid metabolism, and inflammatory factors may promote the development of T2DM macroangiopathy.
[Chemerin as an early marker of metabolic syndrome].
TLDR
Chemerin (CHEM) is a protein synthesized primarily by adiposse tissue and liver that acts both paracrine and autocrine, stimulating adipocytes maturation and differentiation and acts as a chemoattractant for immune cells, regulating the innate and acquired inflammatory response.
Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation
TLDR
A concise overview of “classic” and novel promising adipocytokines associated with AT inflammation is provided and possible critical approaches to their interpretation in clinical practice are discussed.
The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome
TLDR
Serum chemerin levels and non-traditional lipid parameters were correlated significantly with the clinical criteria of MetS and Genotyping and allelic frequency distribution of RARRES2 rs17173608 gene polymorphism showed its significant association with MetS.
Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ
TLDR
Besides serumChemerin, the levels of chemerin/CMKLR1 in the metabolic organs of obesity and diabetes rats were alleviated by exercise, which were likely to be associated with the improvement of glycolipid metabolism.
The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma.
TLDR
Chemerin/ChemR23 promotes tumorigenesis and metastasis in OSCC and may be a new therapeutic target for OSCC.
The Novel Perspectives of Adipokines on Brain Health
TLDR
Five adipokines and two lipokines are reviewed on their roles involving in eating behavior, neurotrophic and neuroprotective factors in the brain, which can lead to novel therapeutic strategies to counteract metabolic associated eating disorders and neurodegenerative diseases.
The Association of Serum Circulating Neuropeptide Q and Chemerin Levels with Cardiometabolic Risk Factors among Patients with Metabolic Syndrome
TLDR
NPQ seems to protect against metabolic disorders correlated with obesity, and it is worth considering NPQ level as a candidate protective biomarker of metabolic syndrome complications.
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References

SHOWING 1-10 OF 98 REFERENCES
Chemerin is associated with markers of inflammation and predictors of atherosclerosis in Saudi subjects with metabolic syndrome and type 2 diabetes mellitus
The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach.
TLDR
The purpose of this review is to examine the mechanisms that link oxidative stress to micro- and macrovascular complications in subjects with type 2 diabetes and to consider the therapeutic opportunities that are presented by currently used therapeutic agents which possess antioxidant properties as well as new potential antioxidant substances.
Inflammation and chemerin in colorectal cancer
TLDR
The results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer.
Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies
TLDR
This review will investigate obese AT biology, initiation of the inflammatory, and insulin resistant environment; and the mechanisms through which dietary anti-inflammatory components/functional nutrients may be beneficial.
Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms
TLDR
Recent progress on insulin resistance and cancer is summarized, focusing on various implicated mechanisms that have been described recently, and how these mechanisms may contribute to cancer initiation and progression are discussed.
Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
TLDR
The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes.
TLDR
It is shown that serum levels of the novel adipokine chemerin are significantly elevated in mouse models of obesity/diabetes and this data indicate thatChemerin influences glucose homeostasis and may contribute to the metabolic derangements characteristic of obesity and type 2 diabetes.
Hepatic Chemerin and Chemokine-Like Receptor 1 Expression in Patients with Chronic Hepatitis C
TLDR
The study for the first time confirmed a marked expression of chemerin and CMKLR1 in the liver of CHC patients and assessed their relationship with metabolic and histopathological abnormalities.
Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation
TLDR
Chemerin and omentin-1 synthesis was dysregulated in MO patients and might play a role in insulin resistance and oxidative stress, and chemerin changes seemed to be predicted mainly by insulin resistance.
Inflammatory mechanisms in obesity.
TLDR
The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research field that examines the inflammatory mechanisms in obesity, and metaflammation is summarized, defined as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess nutrients and energy.
...
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