Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.

@article{Heller2006ChemokineCP,
  title={Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.},
  author={Eric A. Heller and Emerson Liu and Andrew M Tager and Qian Yuan and Alexander Y. T. Lin and Neil Ahluwalia and Krister J Jones and Stephanie L. Koehn and Vincent M. Lok and Elena Aikawa and Kathryn J Moore and Andrew D Luster and Robert E. Gerszten},
  journal={Circulation},
  year={2006},
  volume={113 19},
  pages={
          2301-12
        }
}
BACKGROUND Studies to define the overall contribution of lymphocytes to lesion formation in atherosclerosis-susceptible mice have demonstrated relatively subtle effects; the use of lymphocyte-deficient mice, however, compromises both the effector and regulatory arms of the immune system. Here, we tested the hypothesis that deletion of CXCL10 (IP-10), a chemokine specific for effector T cells that has been localized within atherosclerotic lesions, would significantly inhibit atherogenesis… CONTINUE READING

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