Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus.

@article{Tian2017ChemokineCS,
  title={Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus.},
  author={Dai-Shi Tian and Jiyun Peng and Madhuvika Murugan and Li-Jie Feng and Jun-Li Liu and Ukpong B Eyo and Li-Jun Zhou and Rochelle Mogilevsky and Wei Wang and Long-Jun Wu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2017},
  volume={37 33},
  pages={
          7878-7892
        }
}
Elevated levels of chemokine C-C motif ligand 2 (CCL2) and its receptor CCR2 have been reported in patients with temporal lobe epilepsy and in experimental seizures. However, the functional significance and molecular mechanism underlying CCL2-CCR2 signaling in epileptic brain remains largely unknown. In this study, we found that the upregulated CCL2 was mainly expressed in hippocampal neurons and activated microglia from mice 1 d after kainic acid (KA)-induced seizures. Taking advantage of… CONTINUE READING
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