Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model

@article{Takahashi2009ChemokineCN,
  title={Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model},
  author={Munehisa Takahashi and Hiroshi Miyazaki and Mutsuo Furihata and Hirofumi Sakai and Takeo Konakahara and Morihiro Watanabe and Tomoko N. Okada},
  journal={Clinical & Experimental Metastasis},
  year={2009},
  volume={26},
  pages={817-828}
}
Bone is the most frequent site of breast cancer metastasis, and once such metastasis occurs, complete remission is extremely difficult to achieve. In an effort to define the mechanisms underlying metastatic spread of breast cancer to bone, we previously developed and characterized the highly bone metastatic 4T1E/M3 mouse breast cancer cells. We found that… CONTINUE READING