Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients.

@article{FuentesBeltrn2009ChemokineC5,
  title={Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients.},
  author={A Fuentes-Beltr{\'a}n and Rosal{\'i}a Montes-Vizuet and E. Valencia-Maqueda and Ma. Cristina Negrete-Garcia and Marlen Garc{\'i}a-Cruz and Luis M Ter{\'a}n},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2009},
  volume={39 4},
  pages={491-9}
}
BACKGROUND Airway eosinophilia is a hallmark of aspirin-sensitive asthma/rhinitis. OBJECTIVE We have investigated chemokine CC-ligand 5 (CCL5) production and its association with eosinophil activation in the upper airways of aspirin-sensitive patients both in vivo and in vitro. METHODS Twenty aspirin-sensitive asthma/rhinosinusitis patients, 18 atopic-tolerant asthma/rhinosinusitis patients and 15 healthy control subjects took part in the study. All subjects were challenged with saline and… CONTINUE READING

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