Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia.

  title={Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia.},
  author={Sen-sen Lin and Li Sun and Jialiang Hu and Shuying Wan and Renping Zhao and Shengtao Yuan and Lu-yong Zhang},
  journal={Cancer letters},
  volume={279 1},
The chemokine and chemokine receptor families have important roles in tumorigenesis. Although CXCR4 and CCR7 have been reported to be associated with cancer metastasis, the role of other chemokine receptors in cancer is poorly understood. We explored the status of CXCR6 in hypoxia-induced cell migration. Breast cancer cells and human umbilical vein endothelial cells (HUVEC) expressed CXCR6, and showed appreciable chemotactic migration to CXCL16. Significant accumulation of CXCR6 mRNA and… CONTINUE READING
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The role of CXC chemokines and their receptors in cancer

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