Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain.

@article{Matsushita2014ChemokineM,
  title={Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain.},
  author={Katsuyuki Matsushita and Hidetoshi Tozaki-Saitoh and Chinami Kojima and Takahiro Masuda and Makoto Tsuda and Kazuhide Inoue and Sumio Hoka},
  journal={Anesthesiology},
  year={2014},
  volume={120 6},
  pages={1491-503}
}
BACKGROUND The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS A spinal nerve injury model was established in adult male Wistar rats. The von Frey test and hot plate test were performed to evaluate neuropathic pain behavior, and real-time… CONTINUE READING