Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke.

@article{Cui2009ChemokineVA,
  title={Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke.},
  author={Xu Cui and Michael Chopp and Alex Zacharek and Cynthia Roberts and Mei Lu and Smita Savant-Bhonsale and Jieli Chen},
  journal={Neurobiology of disease},
  year={2009},
  volume={36 1},
  pages={35-41}
}
We investigated the additive therapeutic effect of the combination treatment of stroke with sub-therapeutic doses of Simvastatin, a HMG-CoA reductase inhibitor, and bone marrow stromal cells (BMSCs). Rats were administered Simvastatin (0.5 mg/kg), BMSCs (1x10(6)) or combination of Simvastatin and BMSCs starting at 24 h after stroke. Combination treatment… CONTINUE READING