Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

  title={Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks},
  author={D. Bernardo and M. Thompson and T. S. Gardner and Sarah E Chobot and Erin L Eastwood and Andrew P Wojtovich and S. Elliott and S. Schaus and J. Collins},
  journal={Nature Biotechnology},
  • D. Bernardo, M. Thompson, +6 authors J. Collins
  • Published 2005
  • Biology, Medicine
  • Nature Biotechnology
  • A major challenge in drug discovery is to distinguish the molecular targets of a bioactive compound from the hundreds to thousands of additional gene products that respond indirectly to changes in the activity of the targets. Here, we present an integrated computational-experimental approach for computing the likelihood that gene products and associated pathways are targets of a compound. This is achieved by filtering the mRNA expression profile of compound-exposed cells using a reverse… CONTINUE READING
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