Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma

@article{Nguyn2003ChemogenomicIO,
  title={Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma},
  author={C. Nguy{\^e}n and J. Teo and A. Matsuda and M. Eguchi and E. Chi and W. Henderson and M. Kahn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={1169 - 1173}
}
  • C. Nguyên, J. Teo, +4 authors M. Kahn
  • Published 2003
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Asthma is characterized by an oxidant/antioxidant imbalance in the lungs leading to activation of redox-sensitive transcription factors, nuclear factor κB (NF-κB), and activator protein-1 (AP-1). To develop therapeutic strategies for asthma, we used a chemogenomics approach to screen for small molecule inhibitor(s) of AP-1 transcription. We developed a β-strand mimetic template that acts as a reversible inhibitor (pseudosubstrate) of redox proteins. This template incorporates an enedione moiety… Expand
Chemical genetics: Combichem leads for asthma
  • M. Brazil
  • Medicine
  • Nature Reviews Drug Discovery
  • 2003
Selective antagonism of cJun for cancer therapy
Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1.
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310
Small molecule inhibitors of DNA repair nuclease activities of APE1
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