Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

@inproceedings{Steinhorn2018ChemogeneticGO,
  title={Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction},
  author={Benjamin Steinhorn and Andrea Sorrentino and Sachin Badole and Yulia A Bogdanova and Vsevolod V Belousov and Thomas Michel},
  booktitle={Nature Communications},
  year={2018}
}
Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and cardiac pathology has been observed in multiple models of heart failure, the independent role of hydrogen peroxide (H2O2) in vitro and in vivo is unclear, owing to a lack of tools for precise manipulation of intracellular redox state. Here we apply a… CONTINUE READING

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